Xanax Half Life

By | Nov 26, 2017

Xanax Half-life is a statictical expression of the period of time it takes for a drug to disappear from your body. Theoretically, the “half-life,” expressed as a range, is the period it takes for half of the amount taken to be eliminated from your body, and so on. There is some controversy as to the duration benzodiazepines may really remain in your body after you have withdrawn from using them entirely. Benzodiazepines are fat soluble and can persist in fatty tissues. However, benzodiazepines no longer present in blood screenings beyond 30 days after termination. This either indicates they are totally excreted by that time, or that they persevere in amounts too decreased to have any long term effect.

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The implication of half-life is that a more extended half-life usually makes for a simpler withdrawal because your blood levels remain relatively unvarying, as contrasted to the up and down roller coaster that you experience with short half life benzodiazepines. Besides, longer half-life benzodiazepines entail a less dose micro-management. For example, Valium can be given once every 12 hours, or in some cases, once every 24 hours. Xanax, on the other hand, should be taken once every 4-6 hours to sustain unvarying blood levels. This is a practical impossibility for some people.

The following is an entry of benzodiazepines with their matching half-lives, expressed as a range in hours:

Alprazolam 9 – 20
Bromazepam 8 – 30
Chlordiazepoxide 24 – 100
Clonazepam 19 – 60
Clorazepate 1.3 – 120
Diazepam 30 – 200
Estazolam 8 – 24
Flunitrazepam 18 – 26
Flurazepam 40 – 250
Halazepam 30 – 96
Ketazolam 30 – 200
Lorazepam 8 – 24
Lormetazepam 10 – 12
Nitrazepam 15 – 48
Oxazepam 3 – 25
Prazepam 30 – 100
Quazepam 39 – 120
Temazepam 3 – 25
Triazolam 1.5 – 5

There is a misconception that longer half-life benzodiazepines delay the withdrawal recovery process by staying in your body tissues for longer. on the other hand, there is no verification that longer half-life benzodiazepines indicate any biggerhazard for Protracted Benzodiazepine Withdrawal Syndrome (see below) than shorter half-life benzodiazepines. This manner of choosing a longer half-life equivalent is well stated in addiction medicine circles, and is used withdifferent classes of drugs as well. For example, people who are experiencing withdrawal symptoms from an antidepressant such as Paxil (Seroxat, paroxetine) are usually given Prozac (fluoxetine) as a substitute for purposes of withdrawal, because Prozac has a longer half-life. Perhaps a more typical example is the use of the drug Methadone in heroin detoxification, which is used in part because of its relatively long half-life.

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